The role of liver kinase B1 in tumor progression through regulation of lipid metabolism
Clin. transl. oncol. (Print)
; 24(11): 2045-2054, noviembre 2022.
Article
in En
| IBECS
| ID: ibc-210133
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
The somatic mutation of liver kinase B1 (LKB1) has been implicated in various tumors, which is reflected in the survival, proliferation, and metastasis of tumor cells. However, the regulation of LKB1 in lipid metabolism, a process that is involved in tumor progression is not completely clear. We conclude that LKB1 deficiency results in abnormal expression and activation of multiple molecules related to lipid metabolism which locate downstream of AMP-activated protein kinase (AMPK) or salt-induced kinase (SIK). Abnormal lipid metabolism induced by LKB1 deficiency contributes to the proliferation and metastasis of tumor cells through energy regulation. (AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Mitogen-Activated Protein Kinase Kinases
/
AMP-Activated Protein Kinases
/
Neoplasm Metastasis
Limits:
Humans
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2022
Document type:
Article